Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity.

The murine Pax-3 protein contains two DNA-binding domains, a paired domain and a homeodomain, and alterations in the Pax-3 gene are responsible for the neural tube defects observed in the Splotch (Sp) mouse mutant. Of five Sp alleles, Splotch-delayed (Spd) is the only one that encodes a full-length...

Full description

Saved in:
Bibliographic Details
Main Authors: Underhill, D A, Vogan, K J, Gros, P
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC42027/
https://ncbi.nlm.nih.gov/pubmed/7731966
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items