Acetylation-defective mutants of Pparγ are associated with decreased lipid synthesis in breast cancer cells

In our prior publications we characterized a conserved acetylation motif (K(R)xxKK) of evolutionarily related nuclear receptors. Recent reports showed that peroxisome proliferator activated receptor gamma (PPARγ) deacetylation by SIRT1 is involved in delaying cellular senescence and maintaining the...

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Main Authors: Tian, Lifeng, Wang, Chenguang, Hagen, Fred K., Gormley, Michael, Addya, Sankar, Soccio, Raymond, Casimiro, Mathew C., Zhou, Jie, Powell, Michael J., Xu, Ping, Deng, Haiteng, Sauve, Anthony A., Pestell, Richard G.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
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Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4202124/
https://ncbi.nlm.nih.gov/pubmed/25229978
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