Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1-KRAS-NF-κB Pathway

8-Oxoguanine-DNA glycosylase-1 (OGG1) is the primary enzyme for repairing 7,8-dihydro-8-oxoguanine (8-oxoG) via the DNA base excision repair pathway (OGG1-BER). Accumulation of 8-oxoG in the genomic DNA leads to genetic instability and carcinogenesis, and is thought to contribute to the worsening of...

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Autors principals: Aguilera-Aguirre, Leopoldo, Bacsi, Attila, Radak, Zsolt, Hazra, Tapas K., Mitra, Sankar, Sur, Sanjiv, Brasier, Allan R, Ba, Xueqing, Boldogh, Istvan
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201976/
https://ncbi.nlm.nih.gov/pubmed/25267977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401625
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