Tumor Cell-derived MMP-3 Orchestrates Rac1b and Tissue Alterations that Promote Pancreatic Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) arises at the convergence of genetic alterations in KRAS with a fostering microenvironment shaped by immune cell influx and fibrotic changes; identification of the earliest tumorigenic molecular mediators evokes the proverbial chicken and egg problem. Matrix me...

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Detalhes bibliográficos
Main Authors: Mehner, Christine, Miller, Erin, Khauv, Davitte, Nassar, Aziza, Oberg, Ann L., Bamlet, William R., Zhang, Lizhi, Waldmann, Jens, Radisky, Evette S., Crawford, Howard C., Radisky, Derek C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201965/
https://ncbi.nlm.nih.gov/pubmed/24850902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0557-T
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