Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion

BACKGROUND: Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of metformin in ischemic stroke is unclear. Here, we investigated the effect of metformin on ischemic stroke in mice and further explored the p...

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Hlavní autoři: Liu, Yanqun, Tang, Guanghui, Li, Yaning, Wang, Yang, Chen, Xiaoyan, Gu, Xiang, Zhang, Zhijun, Wang, Yongting, Yang, Guo-Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201919/
https://ncbi.nlm.nih.gov/pubmed/25315906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0177-4
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