Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion

BACKGROUND: Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of metformin in ischemic stroke is unclear. Here, we investigated the effect of metformin on ischemic stroke in mice and further explored the p...

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Detalhes bibliográficos
Main Authors: Liu, Yanqun, Tang, Guanghui, Li, Yaning, Wang, Yang, Chen, Xiaoyan, Gu, Xiang, Zhang, Zhijun, Wang, Yongting, Yang, Guo-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201919/
https://ncbi.nlm.nih.gov/pubmed/25315906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0177-4
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