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Ral small GTPase signaling and oncogenesis: more than just 15 minutes of fame

Since their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of diverse cellular functions. Ral-selective guanine nucleotide exchange factors (RalGEFs) function as downstream effectors of the Ras oncoprotein, and the RalGEF-Ral signaling network comprises the third best...

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Autores principales: Gentry, Leanna R., Martin, Timothy D., Reiner, David J., Der, Channing J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201770/
https://ncbi.nlm.nih.gov/pubmed/25219551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2014.09.004
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