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Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes
With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during pre-implantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA replication-dependent dilution both contribute to global paternal DNA demeth...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4201500/ https://ncbi.nlm.nih.gov/pubmed/25280220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.09.002 |
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