THDP17 Decreases Ammonia Production through Glutaminase Inhibition. A New Drug for Hepatic Encephalopathy Therapy

Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia. Management of ammonia formation can be effective in HE treatment by lowering intestinal ammonia production. The use of glutaminase inhibitors repres...

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Detalhes bibliográficos
Main Authors: Díaz-Herrero, M. Mar, del Campo, José A., Carbonero-Aguilar, Pilar, Vega-Pérez, José M., Iglesias-Guerra, Fernando, Periñán, Ignacio, Miñano, Francisco J., Bautista, Juan, Romero-Gómez, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201470/
https://ncbi.nlm.nih.gov/pubmed/25329718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109787
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