Deletion of P58(IPK), the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice

Objective: Protein kinase-like endoplasmic reticulum kinase (PERK) and protein kinase R (PKR) are implicated in endoplasmic reticulum stress-induced arthritis and pro-inflammatory cytokine-mediated cartilage degradation in vitro, respectively. We determined whether knockout of the cellular inhibitor...

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Main Authors: Gilbert, Sophie J., Meakin, Lee B., Bonnet, Cleo S., Nowell, Mari A., Ladiges, Warren C., Morton, John, Duance, Victor C., Mason, Deborah J.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2014
主題:
Endocrinology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201149/
https://ncbi.nlm.nih.gov/pubmed/25368604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2014.00174
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