The Cellular Protein P58(IPK) Regulates Influenza Virus mRNA Translation and Replication through a PKR-Mediated Mechanism

We previously hypothesized that efficient translation of influenza virus mRNA requires the recruitment of P58(IPK), the cellular inhibitor of PKR, an interferon-induced kinase that targets the eukaryotic translation initiation factor eIF2α. P58(IPK) also inhibits PERK, an eIF2α kinase that is locali...

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Detalhes bibliográficos
Main Authors: Goodman, Alan G., Smith, Jennifer A., Balachandran, Siddharth, Perwitasari, Olivia, Proll, Sean C., Thomas, Matthew J., Korth, Marcus J., Barber, Glen N., Schiff, Leslie A., Katze, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865913/
https://ncbi.nlm.nih.gov/pubmed/17166899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02151-06
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