In Silico Identification of an Aryl Hydrocarbon Receptor Antagonist with Biological Activity In Vitro and In Vivo

The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape–based v...

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Autors principals: Parks, Ashley J., Pollastri, Michael P., Hahn, Mark E., Stanford, Elizabeth A., Novikov, Olga, Franks, Diana G., Haigh, Sarah E., Narasimhan, Supraja, Ashton, Trent D., Hopper, Timothy G., Kozakov, Dmytro, Beglov, Dimitri, Vajda, Sandor, Schlezinger, Jennifer J., Sherr, David H.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201140/
https://ncbi.nlm.nih.gov/pubmed/25159092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.093369
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