In Silico Identification of an Aryl Hydrocarbon Receptor Antagonist with Biological Activity In Vitro and In Vivo

The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape–based v...

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Hlavní autoři: Parks, Ashley J., Pollastri, Michael P., Hahn, Mark E., Stanford, Elizabeth A., Novikov, Olga, Franks, Diana G., Haigh, Sarah E., Narasimhan, Supraja, Ashton, Trent D., Hopper, Timothy G., Kozakov, Dmytro, Beglov, Dimitri, Vajda, Sandor, Schlezinger, Jennifer J., Sherr, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201140/
https://ncbi.nlm.nih.gov/pubmed/25159092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.093369
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