In Silico Identification of an Aryl Hydrocarbon Receptor Antagonist with Biological Activity In Vitro and In Vivo

The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape–based v...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Parks, Ashley J., Pollastri, Michael P., Hahn, Mark E., Stanford, Elizabeth A., Novikov, Olga, Franks, Diana G., Haigh, Sarah E., Narasimhan, Supraja, Ashton, Trent D., Hopper, Timothy G., Kozakov, Dmytro, Beglov, Dimitri, Vajda, Sandor, Schlezinger, Jennifer J., Sherr, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201140/
https://ncbi.nlm.nih.gov/pubmed/25159092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.093369
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados