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Reversible Epigenetic Regulation of 14-3-3σ Expression in Acquired Gemcitabine Resistance by Uhrf1 and DNA Methyltransferase 1

Although gemcitabine is the most commonly used drug for treating pancreatic cancers, acquired gemcitabine resistance in a substantial number of patients appears to hinder its effectiveness in successful treatment of this dreadful disease. To understand acquired gemcitabine resistance, we generated a...

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Main Authors: Qin, Li, Dong, Zizheng, Zhang, Jian-Ting
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201139/
https://ncbi.nlm.nih.gov/pubmed/25189999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.092544
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