DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations

BACKGROUND: The brain is a common target of metastases for melanoma patients. Little is known about the genetic and epigenetic alterations in melanoma brain metastases (MBMs). Unraveling these molecular alterations is a key step in understanding their aggressive nature and identifying novel therapeu...

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Main Authors: Marzese, Diego M., Scolyer, Richard A., Roqué, Maria, Vargas-Roig, Laura M., Huynh, Jamie L., Wilmott, James S., Murali, Rajmohan, Buckland, Michael E., Barkhoudarian, Garni, Thompson, John F., Morton, Donald L., Kelly, Daniel F., Hoon, Dave S. B.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201072/
https://ncbi.nlm.nih.gov/pubmed/24968695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou107
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