Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis

Melanoma brain metastasis (MBM) represents a frequent complication of cutaneous melanoma. Despite aggressive multi-modality therapy, patients with MBM often have a survival rate of <1 year. Alteration in DNA methylation is a major hallmark of tumor progression and metastasis; however, it remains...

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Autori principali: Marzese, Diego M., Scolyer, Richard A., Huynh, Jamie L., Huang, Sharon K., Hirose, Hajime, Chong, Kelly K., Kiyohara, Eiji, Wang, Jinhua, Kawas, Neal P., Donovan, Nicholas C., Hata, Keisuke, Wilmott, James S., Murali, Rajmohan, Buckland, Michael E., Shivalingam, Brindha, Thompson, John F., Morton, Donald L., Kelly, Daniel F., Hoon, Dave S.B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857956/
https://ncbi.nlm.nih.gov/pubmed/24014427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt420
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