OP27 ETOPOSIDE PHARMACOKINETICS FOLLOWING INTRA-CEREBROSPINAL FLUID ADMINISTRATION IN PATIENTS WITH LEPTOMENINGEAL METASTASES

INTRODUCTION: Daily intra-cerebrospinal fluid (CSF) etoposide administration regimens are in use, by-passing the blood-brain-barrier and offering higher CSF drug concentrations at 1/30(th) to 1/340(th) the dose in conventional systemically administered standard and high dose etoposide regimens, resp...

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Autores principales: Meijer, Lisethe, Veal, Gareth, Walker, David, Grundy, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200970/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou251.25
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