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P67 DEFINING A TARGET INTRA-CEREBROSPINAL FLUID STEADY STATE ETOPOSIDE CONCENTRATION [CSF ETOPOSIDE] FOR PHASE I STUDY IN CHILDREN WITH LEPTOMENINGEAL METASTASIS (LM): INTREPID, A FIRST IN MAN STUDY
INTRODUCTION: Continuous intra-CSF etoposide infusion may optimise etoposide pharmacokinetics by bypassing the blood-brain-barrier and compensating for CSF bulk flow removal, at < 1/340th dose of standard regimens. A 3 + 3 phase I study is proposed, escalating target [CSF etoposide] and infusion...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4200934/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou249.53 |
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