P67 DEFINING A TARGET INTRA-CEREBROSPINAL FLUID STEADY STATE ETOPOSIDE CONCENTRATION [CSF ETOPOSIDE] FOR PHASE I STUDY IN CHILDREN WITH LEPTOMENINGEAL METASTASIS (LM): INTREPID, A FIRST IN MAN STUDY

INTRODUCTION: Continuous intra-CSF etoposide infusion may optimise etoposide pharmacokinetics by bypassing the blood-brain-barrier and compensating for CSF bulk flow removal, at < 1/340th dose of standard regimens. A 3 + 3 phase I study is proposed, escalating target [CSF etoposide] and infusion...

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Main Authors: Meijer, Lisethe, Veal, Gareth, Grundy, Richard, Konczalik, Wojchiech, Ivanov, Delyan, Garnett, Martin, Kearns, Pamela, Walker, David
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
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Abstracts
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200934/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou249.53
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