OP12 BORON NEUTRON CAPTURE THERAPY (BNCT): OPTIMISATION OF BORON UPTAKE AND PATIENT STRATIFICATION BY LAT1 IMPROVES BIOLOGICAL TARGETING WITH REDUCED RADIATION TIME, AND INCREASED CHANCE OF TUMOUR CONTROL

INTRODUCTION: The interaction between an epithermal neutron beam, now deliverable with LINAC technology, and tumour cell accumulated Boron from borono-phenylalanine (BPA), releases an intracellular alpha particle and Li ion causing irrecoverable double strand DNA breaks, insensitive to hypoxia and c...

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Main Authors: Cruickshank, G., Detta, A., Ngoga, D., Lockyer, N., Pheonix, B., Ghani, Z., Green, S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200956/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou251.12
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