Estimating Endogenous Dopamine Levels at D(2) and D(3) Receptors in Humans using the Agonist Radiotracer [(11)C]-(+)-PHNO

Using positron emission tomography (PET) and an acute dopamine depletion challenge it is possible to estimate endogenous dopamine levels occupying dopamine D(2/3) receptors (D(2/3)R) in humans in vivo. Our group has developed [(11)C]-(+)-PHNO, the first agonist radiotracer with preferential in vivo...

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Bibliographische Detailangaben
Hauptverfasser: Caravaggio, Fernando, Nakajima, Shinichiro, Borlido, Carol, Remington, Gary, Gerretsen, Philip, Wilson, Alan, Houle, Sylvain, Menon, Mahesh, Mamo, David, Graff-Guerrero, Ariel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200487/
https://ncbi.nlm.nih.gov/pubmed/24874713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.125
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