Aging impairs smooth muscle-mediated regulation of aortic stiffness: a defect in shock absorption function?

Increased aortic stiffness is an early and independent biomarker of cardiovascular disease. Here we tested the hypothesis that vascular smooth muscle cells (VSMCs) contribute significantly to aortic stiffness and investigated the mechanisms involved. The relative contributions of VSMCs, focal adhesi...

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Detalhes bibliográficos
Main Authors: Gao, Yuan Z., Saphirstein, Robert J., Yamin, Rina, Suki, Bela, Morgan, Kathleen G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200340/
https://ncbi.nlm.nih.gov/pubmed/25128168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00392.2014
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