Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach

Oxyntic atrophy in the stomach leads to chief cell transdifferentiation into spasmolytic polypeptide expressing metaplasia (SPEM). Investigations of preneoplastic metaplasias in the stomach are limited by the sole reliance on in vivo mouse models, owing to the lack of in vitro models for distinct no...

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Main Authors: Weis, Victoria G., Petersen, Christine P., Mills, Jason C., Tuma, Pamela L., Whitehead, Robert H., Goldenring, James R.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
Fag:
Mucosal Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200317/
https://ncbi.nlm.nih.gov/pubmed/25190476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00169.2014
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