Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium

We have demonstrated that GLP-1 improved myocardial functional recovery in acute myocardial ischemic injury. However, whether stimulation of the GLP-1 receptor (GLP-1R) with exendin-4, a selective GLP-1R agonist, could initiate a protective effect in the heart remains to be determined. Mouse myocard...

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Main Authors: DeNicola, Megan, Du, Jianfeng, Wang, Zhengke, Yano, Naohiro, Zhang, Ling, Wang, Yigang, Qin, Gangjian, Zhuang, Shougang, Zhao, Ting C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200306/
https://ncbi.nlm.nih.gov/pubmed/25117407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00109.2014
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