EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer

BACKGROUND: GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Gprc5a– knockout mice develop spontaneous lung cancer, indicating Gprc5a is a lung tumor suppressor gene. GPRC5A expression is frequently suppressed in majority of non-small cell lung cancers (NSCLC...

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Bibliografiske detaljer
Main Authors: Lin, Xiaofeng, Zhong, Shuangshuang, Ye, Xiaofeng, Liao, Yueling, Yao, Feng, Yang, Xiaohua, Sun, Beibei, Zhang, Jie, Li, Qi, Gao, Yong, Wang, Yifan, Liu, Jingyi, Han, Baohui, Chin, Y Eugene, Zhou, Binhua P, Deng, Jiong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200229/
https://ncbi.nlm.nih.gov/pubmed/25311788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-233
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