APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model

Several APOBEC3 proteins, particularly APOBEC3D, APOBEC3F, and APOBEC3G, induce G-to-A hypermutations in HIV-1 genome, and abrogate viral replication in experimental systems, but their relative contributions to controlling viral replication and viral genetic variation in vivo have not been elucidate...

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Hauptverfasser: Sato, Kei, Takeuchi, Junko S., Misawa, Naoko, Izumi, Taisuke, Kobayashi, Tomoko, Kimura, Yuichi, Iwami, Shingo, Takaori-Kondo, Akifumi, Hu, Wei-Shau, Aihara, Kazuyuki, Ito, Mamoru, An, Dong Sung, Pathak, Vinay K., Koyanagi, Yoshio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199767/
https://ncbi.nlm.nih.gov/pubmed/25330146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004453
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