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Synthesis and biological investigations of a ZnPc-antiCEA bioconjugate for imaging of colorectal cancer

Two zinc(II) phthalocyanines (ZnPcs) were conjugated with a monoclonal antibody (MAb) directed against carcinoembryonic antigen (CEA), using an in situ activated carboxylic acid on the ZnPcs. The bioconjugate with the highest ZnPc/MAb ratio of 3 was investigated in vitro for its ability to target an...

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Autori principali: Sehgal, Inder, Li, Hairong, Ongarora, Benson, Devillier, Daniel, Vicente, M. Graça H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199585/
https://ncbi.nlm.nih.gov/pubmed/25328375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1142/S108842461250143X
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