Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

In COPD, matrix remodeling contributes to airflow limitation. Recent evidence suggests that next to fibroblasts, the process of epithelial-mesenchymal transition can contribute to matrix remodeling. CSE has been shown to induce EMT in lung epithelial cells, but the signaling mechanisms involved are...

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Autori principali: Eurlings, Irene M. J., Reynaert, Niki L., van den Beucken, Twan, Gosker, Harry R., de Theije, C. C., Verhamme, Fien M., Bracke, Ken R., Wouters, Emiel F. M., Dentener, Mieke A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199572/
https://ncbi.nlm.nih.gov/pubmed/25329389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107757
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