Hepatotoxicity in Mice of a Novel Anti-parasite Drug Candidate Hydroxymethylnitrofurazone: A Comparison with Benznidazole

BACKGROUND: Treatment of Chagas disease, caused by Trypanosoma cruzi, relies on nifurtimox and benznidazole (BZL), which present side effects in adult patients, and natural resistance in some parasite strains. Hydroxymethylnitrofurazone (NFOH) is a new drug candidate with demonstrated trypanocidal a...

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Detalhes bibliográficos
Main Authors: Davies, Carolina, Dey, Nilay, Negrette, Olga Sanchez, Parada, Luis Antonio, Basombrio, Miguel A., Garg, Nisha Jain
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199569/
https://ncbi.nlm.nih.gov/pubmed/25329323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003231
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