Lovastatin Inhibits Low Molecular Weight Hyaluronan Induced Chemokine Expression via LFA-1 and Decreases Bleomycin-Induced Pulmonary Fibrosis

BACKGROUND: Lovastatin has a unique ability to bind Leukocyte Function Antigen-1 (LFA-1), an integrin necessary for the full expression of inflammatory cytokines induced by the low molecular weight form of the extracellular matrix glycosaminoglycan hyaluronan (LMW HA). We hypothesized that lovastati...

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Autores principales: Hamblin, Mark J., Eberlein, Michael, Black, Katharine, Hallowell, Robert, Collins, Samuel, Chan-Li, Yee, Horton, Maureen R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Master Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199473/
https://ncbi.nlm.nih.gov/pubmed/25324695
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