Evolutionarily diverse determinants of meiotic DNA break and recombination landscapes across the genome

Fission yeast Rec12 (Spo11 homolog) initiates meiotic recombination by forming developmentally programmed DNA double-strand breaks (DSBs). DSB distributions influence patterns of heredity and genome evolution, but the basis of the highly nonrandom choice of Rec12 cleavage sites is poorly understood,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fowler, Kyle R., Sasaki, Mariko, Milman, Neta, Keeney, Scott, Smith, Gerald R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2014
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199369/
https://ncbi.nlm.nih.gov/pubmed/25024163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.172122.114
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