PICALM modulates autophagy activity and tau accumulation

Genome-wide association studies have identified several loci associated with Alzheimer’s disease (AD), including proteins involved in endocytic trafficking such as PICALM/CALM (phosphatidylinositol binding clathrin assembly protein). It is unclear how these loci may contribute to AD pathology. Here...

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Autors principals: Moreau, Kevin, Fleming, Angeleen, Imarisio, Sara, Lopez Ramirez, Ana, Mercer, Jacob L., Jimenez-Sanchez, Maria, Bento, Carla F., Puri, Claudia, Zavodszky, Eszter, Siddiqi, Farah, Lavau, Catherine P., Betton, Maureen, O’Kane, Cahir J., Wechsler, Daniel S., Rubinsztein, David C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199285/
https://ncbi.nlm.nih.gov/pubmed/25241929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5998
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