Runx1 is required for progression of CD41(+) embryonic precursors into HSCs but not prior to this

Haematopoiesis in adult animals is maintained by haematopoietic stem cells (HSCs), which self-renew and can give rise to all blood cell lineages. The AGM region is an important intra-embryonic site of HSC development and a wealth of evidence indicates that HSCs emerge from the endothelium of the emb...

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Detalhes bibliográficos
Main Authors: Liakhovitskaia, Anna, Rybtsov, Stanislav, Smith, Tom, Batsivari, Antoniana, Rybtsova, Natalia, Rode, Christina, de Bruijn, Marella, Buchholz, Frank, Gordon-Keylock, Sabrina, Zhao, Suling, Medvinsky, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Stem Cells and Regeneration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199125/
https://ncbi.nlm.nih.gov/pubmed/25139854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.110841
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