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Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

Insulin resistance is a pathophysiological component of type 2 diabetes and obesity and also occurs in states of stress, infection, and inflammation associated with an upregulation of cytokines. Here we show that in both obesity and lipopolysaccharide (LPS)-induced endotoxemia there is an increase i...

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Detalhes bibliográficos
Main Authors: Ueki, Kohjiro, Kondo, Tatsuya, Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC419873/
https://ncbi.nlm.nih.gov/pubmed/15169905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.12.5434-5446.2004
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