Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

Insulin resistance is a pathophysiological component of type 2 diabetes and obesity and also occurs in states of stress, infection, and inflammation associated with an upregulation of cytokines. Here we show that in both obesity and lipopolysaccharide (LPS)-induced endotoxemia there is an increase i...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Ueki, Kohjiro, Kondo, Tatsuya, Kahn, C. Ronald
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2004
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419873/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15169905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.12.5434-5446.2004
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