MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is characterized by the t(15;17)-associated PML-RARA fusion gene. We have previously found that MIR125B1 is highly expressed in patients with APL and may be associated with disease pathogenesis; however, the mechanism by which MIR125B1 exerts its oncogenic potentia...

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Detalhes bibliográficos
Main Authors: Zeng, Cheng-Wu, Chen, Zhen-Hua, Zhang, Xing-Ju, Han, Bo-Wei, Lin, Kang-Yu, Li, Xiao-Juan, Wei, Pan-Pan, Zhang, Hua, Li, Yangqiu, Chen, Yue-Qin
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198358/
https://ncbi.nlm.nih.gov/pubmed/25126724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.29592
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