Phase I Study of Preoperative Radiation Therapy with Concurrent Infusional 5-Fluorouracil and Oxaliplatin followed by Surgery and Postoperative 5- Fluorouracil plus Leucovorin for T3/4 Rectal Adenocarcinoma: ECOG E1297

PURPOSE: Oxaliplatin is a platinum analog and radiosensitizer active in colorectal cancer. We performed a phase I trial to test the safety and preliminary efficacy of adding oxaliplatin to standard preoperative chemoradiation therapy for rectal cancer. PATIENTS AND METHODS: Eligible patients had T3-...

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Autori principali: Rosenthal, David I., Catalano, Paul J., Haller, Daniel G., Landry, Jerome C., Sigurdson, Elin R., Spitz, Francis R., Benson, Al Bowen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198328/
https://ncbi.nlm.nih.gov/pubmed/18722265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2008.05.054
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