Phase II Trial of Preoperative Radiation With Concurrent Capecitabine, Oxaliplatin, and Bevacizumab Followed by Surgery and Postoperative 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX), and Bevacizumab in Patients With Locally Advanced Rectal Cancer: 5-Year Clinical Outcomes ECOG-ACRIN Cancer Research Group E3204

LESSONS LEARNED: The 5-year oncologic outcomes from the trial regimen were excellent. However, the neoadjuvant and surgical toxicity of this regimen was significant and was the primary reason for the low compliance with adjuvant systemic therapy. Due to the lack of an improvement in the pathologic c...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Landry, Jerome C., Feng, Yang, Prabhu, Roshan S., Cohen, Steven J., Staley, Charles A., Whittington, Richard, Sigurdson, Elin Ruth, Nimeiri, Halla, Verma, Udit, Benson, Al Bowen
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2015
Assuntos:
Clinical Trial Results
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571787/
https://ncbi.nlm.nih.gov/pubmed/25926352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0106
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