UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency,...

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Detalhes bibliográficos
Main Authors: Oka, Yasuyoshi, Varmark, Hanne, Vitting-Seerup, Kristoffer, Beli, Petra, Waage, Johannes, Hakobyan, Anna, Mistrik, Martin, Choudhary, Chunaram, Rohde, Mikkel, Bekker-Jensen, Simon, Mailand, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198039/
https://ncbi.nlm.nih.gov/pubmed/25092792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438679
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