UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency,...

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Bibliografiska uppgifter
Huvudupphovsmän: Oka, Yasuyoshi, Varmark, Hanne, Vitting-Seerup, Kristoffer, Beli, Petra, Waage, Johannes, Hakobyan, Anna, Mistrik, Martin, Choudhary, Chunaram, Rohde, Mikkel, Bekker-Jensen, Simon, Mailand, Niels
Materialtyp: Artigo
Språk:Inglês
Publicerad: BlackWell Publishing Ltd 2014
Ämnen:
Scientific Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198039/
https://ncbi.nlm.nih.gov/pubmed/25092792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438679
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