Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease

The heterocyclic aldehyde 5-hydroxymethyl-2-furfural (5HMF) interacts allosterically with the abnormal form of haemoglobin (Hb), HbS, in red blood cells (RBCs) from patients with sickle cell disease (SCD), thereby increasing oxygen affinity and decreasing HbS polymerization and RBC sickling during h...

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Bibliografische gegevens
Hoofdauteurs: Hannemann, Anke, Cytlak, Urszula M, Rees, David C, Tewari, Sanjay, Gibson, John S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Science Inc 2014
Onderwerpen:
Cardiovascular
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198013/
https://ncbi.nlm.nih.gov/pubmed/25015917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.277681
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