The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2

Cell type-specific conditional activation of oncogenic K-Ras is a powerful tool for investigating the cell of origin of adenocarcinomas in the mouse lung. Our previous studies showed that K-Ras activation with a CC10(Scgb1a1)-CreER driver leads to adenocarcinoma in a subset of alveolar type II cells...

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Bibliografiske detaljer
Main Authors: Xu, Xia, Huang, Lingling, Futtner, Christopher, Schwab, Brian, Rampersad, Rishi R., Lu, Yun, Sporn, Thomas A., Hogan, Brigid L.M., Onaitis, Mark W.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197950/
https://ncbi.nlm.nih.gov/pubmed/25184679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.243717.114
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