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Cancer and Altered Metabolism: Potential Importance of HIF and 2-Oxoglutarate-dependent Dioxygenases
Otto Warburg noted decades ago that cancer cells maintain very high rates of glycolysis, converting glucose to lactate, despite sufficient oxygen to perform oxidative-phosphorylation, which is the more efficient means of generating energy (ATP) from glucose. This conundrum has generated considerable...
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| Natura: | Artigo |
| Lingua: | Inglês |
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2011
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197849/ https://ncbi.nlm.nih.gov/pubmed/22089927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/sqb.2011.76.010975 |
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