SirT1 is required in the male germ cell for differentiation and fecundity in mice

Sirtuins are NAD(+)-dependent deacylases that regulate numerous biological processes in response to the environment. SirT1 is the mammalian ortholog of yeast Sir2, and is involved in many metabolic pathways in somatic tissues. Whole body deletion of SirT1 alters reproductive function in oocytes and...

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Detalhes bibliográficos
Principais autores: Bell, Eric L., Nagamori, Ippei, Williams, Eric O., Del Rosario, Amanda M., Bryson, Bryan D., Watson, Nicki, White, Forest M., Sassone-Corsi, Paolo, Guarente, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197722/
https://ncbi.nlm.nih.gov/pubmed/25142464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.110627
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