A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions

BACKGROUND: To generate a replication-competent retrovirus that could be conditionally inactivated, we flanked the viral genes of the Akv murine leukemia virus with LoxP sites. This provirus can delete its envelope gene by LoxP/Cre mediated recombination and thereby allow superinfection of Cre recom...

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Publicat a:Retrovirology
Autors principals: Wang, Clifford L, Hodgson, J Graeme, Malek, Tiffany, Pedersen, Finn Skou, Wabl, Matthias
Format: Artigo
Idioma:Inglês
Publicat: BMC 2004
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419723/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15169571/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1742-4690-1-5
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