CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway

Mutations in CFTR lead to dysfunction of tubular organs, which is currently attributed to impairment of its conductive properties. We now show that CFTR regulates tight junction assembly and epithelial cell differentiation through modulation of the ZO-1–ZONAB pathway. CFTR colocalizes with ZO-1 at t...

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Detaylı Bibliyografya
Asıl Yazarlar: Ruan, Ye Chun, Wang, Yan, Da Silva, Nicolas, Kim, Bongki, Diao, Rui Ying, Hill, Eric, Brown, Dennis, Chan, Hsiao Chang, Breton, Sylvie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197086/
https://ncbi.nlm.nih.gov/pubmed/25107366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.148098
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