CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway

Mutations in CFTR lead to dysfunction of tubular organs, which is currently attributed to impairment of its conductive properties. We now show that CFTR regulates tight junction assembly and epithelial cell differentiation through modulation of the ZO-1–ZONAB pathway. CFTR colocalizes with ZO-1 at t...

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Hlavní autoři: Ruan, Ye Chun, Wang, Yan, Da Silva, Nicolas, Kim, Bongki, Diao, Rui Ying, Hill, Eric, Brown, Dennis, Chan, Hsiao Chang, Breton, Sylvie
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197086/
https://ncbi.nlm.nih.gov/pubmed/25107366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.148098
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