CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway

Mutations in CFTR lead to dysfunction of tubular organs, which is currently attributed to impairment of its conductive properties. We now show that CFTR regulates tight junction assembly and epithelial cell differentiation through modulation of the ZO-1–ZONAB pathway. CFTR colocalizes with ZO-1 at t...

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Detalhes bibliográficos
Main Authors: Ruan, Ye Chun, Wang, Yan, Da Silva, Nicolas, Kim, Bongki, Diao, Rui Ying, Hill, Eric, Brown, Dennis, Chan, Hsiao Chang, Breton, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197086/
https://ncbi.nlm.nih.gov/pubmed/25107366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.148098
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