CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway

Mutations in CFTR lead to dysfunction of tubular organs, which is currently attributed to impairment of its conductive properties. We now show that CFTR regulates tight junction assembly and epithelial cell differentiation through modulation of the ZO-1–ZONAB pathway. CFTR colocalizes with ZO-1 at t...

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Opis bibliograficzny
Główni autorzy: Ruan, Ye Chun, Wang, Yan, Da Silva, Nicolas, Kim, Bongki, Diao, Rui Ying, Hill, Eric, Brown, Dennis, Chan, Hsiao Chang, Breton, Sylvie
Format: Artigo
Język:Inglês
Wydane: The Company of Biologists 2014
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197086/
https://ncbi.nlm.nih.gov/pubmed/25107366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.148098
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