CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway

Mutations in CFTR lead to dysfunction of tubular organs, which is currently attributed to impairment of its conductive properties. We now show that CFTR regulates tight junction assembly and epithelial cell differentiation through modulation of the ZO-1–ZONAB pathway. CFTR colocalizes with ZO-1 at t...

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Bibliografische gegevens
Hoofdauteurs: Ruan, Ye Chun, Wang, Yan, Da Silva, Nicolas, Kim, Bongki, Diao, Rui Ying, Hill, Eric, Brown, Dennis, Chan, Hsiao Chang, Breton, Sylvie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197086/
https://ncbi.nlm.nih.gov/pubmed/25107366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.148098
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