The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes

Inflammatory cells acquire a polarized phenotype to migrate towards sites of infection or injury. A conserved polarity complex comprising PAR-3, PAR-6 and atypical protein kinase C (aPKC) relays extracellular polarizing cues to control cytoskeletal and signaling networks affecting morphological and...

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Main Authors: Crespo, Carolina Lage, Vernieri, Claudio, Keller, Philipp J., Garrè, Massimiliano, Bender, Jeffrey R., Wittbrodt, Joachim, Pardi, Ruggero
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197085/
https://ncbi.nlm.nih.gov/pubmed/25179599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.146217
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