SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development

Small ubiquitin-like modifier (SUMO1–3) conjugation plays a critical role in embryogenesis. Embryos deficient in the SUMO-conjugating enzyme Ubc9 die at the early postimplantation stage. Sumo1(−/−) mice are viable, as SUMO2/3 can compensate for most SUMO1 functions. To uncover the role of SUMO2/3 in...

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Bibliografski detalji
Glavni autori: Wang, Liangli, Wansleeben, Carolien, Zhao, Shengli, Miao, Pei, Paschen, Wulf, Yang, Wei
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Scientific Reports
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197045/
https://ncbi.nlm.nih.gov/pubmed/24891386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438534
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