IFITM3 Polymorphism rs12252-C Restricts Influenza A Viruses

The IFITM3 polymorphism rs12252-C, which encodes an IFITM3 isoform (Δ21 IFITM3) lacking 21 amino acids at the amino terminus, has been controversially associated with poor clinical outcomes in patients with H1N1 influenza A virus (IAV) infections. In vitro studies have shown that Δ21 IFITM3 loses it...

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Main Authors: Williams, David Evan Joseph, Wu, Wan-Lin, Grotefend, Christopher Robert, Radic, Vladimir, Chung, Changik, Chung, Young-Hwa, Farzan, Michael, Huang, I-Chueh
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196997/
https://ncbi.nlm.nih.gov/pubmed/25314048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110096
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