Δ20 IFITM2 differentially restricts X4 and R5 HIV-1

CCR5 (R5)-tropic, but not CXCR4 (X4)-tropic, HIV-1 is associated with primary HIV-1 infection and transmission. Recent studies have shown that IFN-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, restrict a broad range of viruses. Here, we demonstrate that an IFITM2 isof...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wu, Wan-Lin, Grotefend, Christopher Robert, Tsai, Ming-Ting, Wang, Yi-Ling, Radic, Vladimir, Eoh, Hyungjin, Huang, I-Chueh
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502592/
https://ncbi.nlm.nih.gov/pubmed/28630320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619640114
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